Treatment Extension in Isoniazid [H] Mono/Poly DR-TB Regimen

The standard duration of the H Mono/ Poly DR-TB regimen is 6 months.

 

The treatment duration may be extended in the following conditions:

 

  • Patients with extensive disease
  • Uncontrolled comorbidity
  • Extra-pulmonary TB
  • Smear at the end of month 4 is found positive
  • When the regimen is modified

Whenever extending treatment, always it is extended directly to 9 months. There is no monthly extension in this regimen.

Eligibility Criteria for Longer Oral M/XDR-TB Regimen

Longer oral Multi (M)/ Extensively-drug Resistant TB (XDR-TB) regimen is recommended for Multi-drug Resistant (MDR)/ Rifampicin-resistant TB (RR-TB) patients who are excluded from shorter oral Bedaquiline-containing MDR/ RR-TB regimen including for the XDR-TB patient. 

 

A patient would be re-evaluated in any of the following conditions and initiated on a longer oral M/XDR-TB regimen at Nodal (N)/ District DR-TB Centre (DDR-TBC) with any modifications:

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