Importance , content of label, where to put, how to put

size, instruction, compartment, colour, silica gel, labeling of PWMB

Why Packaging is required- Loose drugs received, DR-TB PWMB to be prepared at state-level based on treatment regimen(age and weight of patient)

Cartridge-based Nucleic Acid Amplification Testing (CBNAAT) cartridges and Truenat chips are used in the molecular test for TB diagnosis.

Flow chart along with description

In Ziehl-Neelsen microscopy, the carbol fuchsin fuchsin stain is heated to enable the dye to penetrate and bind the waxy mycobacterial cell wall. Following acid-decolourisation, the sputum smear is counterstained with methylene blue which stains the background material, providing a contrast blue colour against which the red AFB can be seen.

• Delamanid (Dlm) is  a second line anti TB drug for Drug Resistant (DR) TB patients, supplied in the form of strips containing 8 tablets having dosage strength of 50mg with 60 months of shelf life. According to National TB Elimination Program (NTEP) guidelines, total 84 strips of Dlm tablets (672 tablets) are required to complete a full course for a patient (i.e, 100mg BD daily dosage) for 6 months of Intensive Phase (IP).

Bedaquiline (Bdq) is a group A second line drug supplied as a jar containing 188 tablets having dosage strength of 100mg with 24 months of shelf life. The jar contains the dosages for entire 6 month of treatment duration.

Flow of Bedaquiline (Bdq) drug in NTEP

Drug-Susceptible Tuberculosis (DS-TB) drugs are available as Fixed Dose Combination. The treatment duration is generally 6-8 months. Weight-band-wise monthly strips are issued to the patient.

There is a significant difference between the flow of DS-TB drugs and Drug-Resistant Tuberculosis (DR-TB) drugs under the National TB Elimination Program (NTEP).  The process of DS-TB drug flow in NTEP is explained below:

Flow chart along with description