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In adults, the dosage of drugs for a shorter oral Bedaquiline (Bdq) - containing Multi-drug Resistant (MDR)/ Rifampicin-resistant Tuberculosis (RR-TB) regimen, varies according to their weight.
The table below provides drug dosages for adult patients, according to their weight bands, in a shorter oral Bedaquiline-containing MDR/RR-TB regimen.
|
Sr No |
Drugs |
16-29 kg |
30-45 kg |
46-70 kg |
>70 kg |
|---|---|---|---|---|---|
|
1 |
High dose H (Hh) |
300 mg |
600 mg |
900 mg |
900 mg |
|
2 |
Ethambutol (E) |
400 mg |
800 mg |
1200 mg |
1600 mg |
|
3 |
Pyrazinamide (Z) |
750 mg |
1250 mg |
1750 mg |
2000 mg |
|
4 |
Levofloxacin (Lfx) |
250 mg |
750 mg |
1000 mg |
1000 mg |
|
5 |
Bedaquiline (Bdq) |
Week 0–2: Bdq 400 mg daily Week 3–24: Bdq 200 mg 3 times per week |
|||
|
6 |
Clofazimine (Cfz) |
50 mg |
100 mg |
100 mg |
200 mg |
|
7 |
Ethionamide (Eto)* |
375 mg |
500 mg |
750 mg |
1000 mg |
|
8 |
Pyridoxine (Pdx) |
50 mg |
100 mg |
100 mg |
100 mg |
| *Drugs can be given in divided doses in a day in the event of intolerance. | |||||
Resources
- Guidelines for Programmatic Management of Drug-resistant Tuberculosis in India, March 2021.
- The Use of Bedaquiline in the Treatment of Multidrug-resistant Tuberculosis: Interim Policy Guidance, 2013.
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