Dosages of M/XDR-TB Drugs for Adult in Longer Oral M/XDR-TB Regimen​

1

Levofloxacin (Lfx)

250 mg

750 mg

1000 mg

1000 mg

2

Moxifloxacin (Mfx)

200 mg

400 mg

400 mg

400 mg

3

High dose Mfx (Mfx^h)

400 mg

600 mg

600 mg

600 mg

4

Bedaquiline (Bdq)

Week 0–2: Bdq 400 mg daily 

Week 3–24: Bdq 200 mg 3 times per week

5

Clofazimine (Cfz)

50 mg

100 mg

100 mg

200 mg

6

Cycloserine (Cs)³

250 mg

500 mg

750 mg

1000 mg

7

Linezolid (Lzd)

300 mg

600 mg

600 mg

600 mg

8

Delamanid (Dlm)

50 mg twice daily (100 mg) for 24 weeks in 6-11 years of age

 100 mg twice daily (200 mg) for 24 weeks for ≥12 years of age

9

Amikacin (Am)¹

500 mg

750 mg

750 mg

1000 mg

10

Pyrazinamide (Z)

750 mg

1250 mg

1750 mg

2000 mg

11

Ethionamide (Eto)³

375 mg

500 mg

750 mg

1000 mg

12

Na - PAS (60% weight/ vol)^2,3 

10 gm

14 gm

16 gm

22 gm

13

Ethambutol (E)

400 mg

800 mg

1200 mg

1600 mg

14

Imipenem-Cilastatin (Imp-Cln)³

2 vials (1g + 1g) bd (to be used with Clavulanic acid)

15

Meropenems (Mpm)³

1000 mg three times daily (alternative dosing is 2000 mg twice daily) (to be used with Clavulanic acid)

16

Amoxicillin-Clavulanate (Amx-Clv) (to be given with Carbapenems only)

875/125 mg bd

875/125 mg bd

875/125 mg bd

875/125 mg bd

17

Pyridoxine (Pdx)

50 mg

100 mg

100 mg

100 mg

¹For adults more than 60 years of age, the dose of Second-line Injectable (SLI) should be reduced to 10 mg/kg (max up to 750 mg).

²In patients of Para Amino Salicylic Acid (PAS) with 80% weight/ volume the dose will be changed to 7.5 gm (16-29 kg); 10 gm (30-45 Kg); 12 gm (46-70 kg) and 16 gm (>70 kg).

³Drugs can be given in divided doses in a day in the event of intolerance.