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The reconstitution of Bedaquiline (Bdq) bottle should be done at the State Drug Store (SDS).
In case of lost to follow-up/ death/ transferred-out/ treatment stopped patients, Bdq bottle shall be brought back from the treatment centre to the Health Facility (HF) to the TB Unit (TU) to the District TB Centre (DTC) within the shortest possible time.
Packaging of loose drugs into monthly patient-wise boxes should be done under the guidance of those in charge of drug logistics at the state and district levels.
Patient-wise drug box preparation should be done for the following Drug-resistant TB (DR-TB) regimens:
Adverse Drug Events are classified on the basis of severity:
1. Serious Adverse Event (SAE) is any untoward medical occurrence that at any dose:
The National TB Elimination Programme (NTEP) utilizes different coloured bags for the segregation of waste generated in TB laboratory settings as shown in the table below.
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Yellow bag: |
Fluorescence microscopy (FM) is used for TB detection and requires specific tools and reagents which are quality assured.
Following are the tools used for Fluorescence Microscopy (FM) staining:
Reagents used for FM staining are: 0.5% Potassium Permanganate, 1% Acid Alcohol and 0.1% Auramine O
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The National TB Elimination Program (NTEP) recommends freshly preparing reagents from commercial procured products, at the District TB units to be used for microscopy. Chemicals need to be carefully monitored for potency and the calculation needs to be accurate while preparing reagents for smear microscopy.
For Preparing 1% Carbol Fuchsin (500ml): The required chemicals and materials for preparing 500 ml Carbol Fuchsin are:
1. Basic Fuchsin
Standard Operating Procedure (SOP) for Packaging Specimen during the transportation of biological specimens for TB diagnosis, also known as Triple Layer Packaging, is as follows:
The Lab Technicians (LTs) at the Designated Microscopy Centres (DMCs) should be trained to carefully pack the sputum samples in the cold box to avoid spillage of the samples. Before packing, personal protection measures such as wearing hand gloves (double gloves preferred), goggles and masks are to be followed by the LTs to prevent contracting the infection.
The Healthcare Worker (HCW) needs to carefully explain how to collect a good quality sputum specimen. He/she needs to demonstrate how to bring up sputum from the chest, what a good sputum specimen looks like, and the quantity of sputum required.
Characteristics of a Good Sputum Sample
Presumptive Drug-resistant TB (DR-TB) in Children
It occurs mostly in children who:
To increase support for Tuberculosis (TB) patients coming from the private sector, the National TB Elimination Programme (NTEP) has affirmed that public health response to all TB patients notified from the private sector will be the responsibility of the public health system.
Patients support services like adherence support, drug susceptibility testing, comorbidity detection, recording treatment outcomes, and infection prevention measures are already being extended to patients in the private sector.