Adverse Drug Reactions(ADRs) to First Line Treatment

Symptoms

Drug Responsible

Action to be taken by Community Health Volunteers

Gastrointestinal Symptoms 

Any Oral Medications

• Reassure patient. 

• Give TB Drugs with less water at a longer interval. 

• If symptom persists, refer to the nearest health facility

Itching/Rashes  

Isoniazid

• Reassure patient. 

• In case of severe itching, refer the patient to the nearest health facility

Tingling/ burning/ numbness in the hands & feet 

Isoniazid

• Refer the patient to the nearest health facility

Joint Pains 

Pyrazinamide

• Reassure patient. 

• Increase intake of liquids. 

• If severe, refer the patient to the nearest health facility

Impaired Vision  

Ethambutol

• Refer the patient to the nearest health facility

Ringing in the ears, Loss of hearing, Dizziness and loss of balance  

Isoniazid, Rifampicin or Pyrazinamide

• Refer the patient to the nearest health facility

Hepatitis: Anorexia/ nausea/ vomiting/ jaundice  

Isoniazid, Ethambutol,  Rifampicin or Pyrazinamide

• If patient detected with signs of jaundice, refer the patient to the nearest health facility