Possible Adverse Events Due to Drugs in Shorter Oral Bedaquiline-containing MDR/RR-TB Regimen

Content Status

Published on LMS

Type

Linked Node

Possible Adverse Events Due to Drugs in Shorter Oral Bedaquiline-containing MDR/RR-TB Regimen

Content

Drugs that are part of the shorter Bedaquiline (Bdq)-containing regimen have some typical side effects which need close monitoring of Drug Resistant-TB (DR-TB) patients while providing the treatment.

Table: Possible adverse events due to drugs in the shorter oral Bedaquiline-containing MDR/RR-TB regimen; Source: Guidelines for PMDT in India, 2021.
Adverse Drug Events	Causative Drugs
QT prolongation	Bdq, Fluoroquinolone (FQ), Clofazimine (Cfz)
Rash, allergic reaction and anaphylaxis	Any drug
Gastrointestinal symptoms	Ethionamide (Eto), Pyrazinamid (Z), Ethambutol (E), Bdq, Cfz, FQs, Isoniazid(H)
Diarrhoea and/or flatulence	Eto
Hepatitis	Z, H, Eto, Bdq
Giddiness	Eto, FQ, Z
Hypothyroidism	Eto
Arthralgia	Z, FQ, Bdq
Peripheral neuropathy	H, FQ, rarely Eto, E
Headache	Bdq
Depression	FQ, H, Eto
Psychotic symptoms	Isoniazid (H), FQ
Suicidal ideation	H, Eto
Seizures	H, FQ
Tendonitis and tendon rupture	FQ
Vestibular toxicity (tinnitus and dizziness)	FQs, H, Eto
Optic neuritis	E, Lzd, Eto, Cfz, H
Metallic taste	Eto, FQs
Gynaecomastia	Eto
Alopecia	H, Eto
Superficial fungal Infection and thrush	FQ
Dysglycaemia and Hyperglycaemia	Eto