Constituents of Monthly Patient-wise Boxes [PWB] for Shorter Oral Bedaquiline-containing MDR/RR-TB Regimen

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Constituents of Monthly Patient-wise Boxes [PWB] for Shorter Oral Bedaquiline-containing MDR/RR-TB Regimen

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The patient on shorter oral Bedaquiline-containing multi-drug resistant (MDR)/rifampicin resistant TB (RR-TB) regimen shall be put on Type A and Type B box when initiated on treatment on a monthly patient wise box (PWB). Bedaquiline (Bdq) needs to be issued separately and stopped after 6 months. The patient should be provided with only Type A boxes when started on continuation phase (CP).

Table 1: Constituents of monthly-type A and B PWB of shorter oral Bedaquiline-containing MDR/RR-TB regimen; *Source : Guidelines for PMDT, India 2021, p.132-133*
TYPE A BOX	(USE IN IP AS WELL AS CP)
Drugs	Strength	16-29 kg	30-45 kg	46-70 kg	>70 kg
Tab. Levofloxacin#	250/500 mg	250 mg *30tab	250 mg 30tab + 500 mg 30tab	500 mg *60tab	500 mg *60tab
Tab. Clofazimine	50/100 mg	50 mg *30tab	100 mg *30tab	100mg *30tab	100 mg *60tab
Tab. Ethambutol	400/800 mg	400 mg *30tab	800 mg *30tab	400 mg 30tab + 800 mg 30tab	800 mg *60tab
Tab. Pyrazinamide	500/750 mg	750 mg *30tab	500 mg 30tab + 750 mg 30tab	500 mg 60tab + 750 mg 30tab	500 mg 30tab + 750 mg 60tab
Tab. Pyridoxine	50/100 mg	50 mg*30tab	100 mg*30tab	100 mg*30tab	100 mg*30tab
Type B Box	(Use in IP)
Drugs	Strength	16-29 kg	30-45 kg	46-70 kg	>70 kg
Tab. Isoniazid	100/300 mg	300 mg *30tab	300 mg *60tab	300 mg *90tab	300 mg *90tab
Tab. Ethionamide	125/250 mg	125 mg 30tab + 250 mg 30tab	250 mg *60tab	250 mg *90tab	250 mg *120tab
Bedaquiline bottle	100 mg	1 Jar (Jar of 188 tablets for full course)
# When moxifloxacin prescribed under exceptional condition instead of levofloxacin, the modified box with moxifloxacin (normal dose) can be prepared from standard box at district drug store (DDS)