Regimen, Duration and Dosage for Isoniazid [H] Mono/Poly DR-TB Regimen

Isoniazid (H) mono/ poly Drug-resistant TB (DR-TB) regimen has the following regimen, duration and dosage of drugs.

Regimen: (6 or 9) Lfx R E Z

Dosage

• The dosage of drugs would vary as per the weight of the patients.
• Adult patients (≥ 18 years) would be classified in weight bands of <16 kg, 16-29 kg, 30-45 kg, 46-70 kg and 70 kg. The drug dosages by these weight bands are shown in the table below.
• All drugs in the regimen are to be given on a daily basis under observation.

Duration

• H mono/ poly DR-TB regimen is for 6 or 9 months with no separate Intensive Phase (IP)/ Continuation Phase (CP).
• In exceptional situations of unavailability of loose drug R or E or Z, the use of 4 FDC (HREZ) with Levofloxacin (Lfx) loose tablets may be considered as an option rather than not starting the H mono/ poly DR-TB patients on treatment.

Resources

• Guidelines for Programmatic Management of Drug-resistant Tuberculosis in India, March 2021.
• WHO Consolidated Guidelines on Tuberculosis: Module 4 - Treatment: Drug-resistant TB Treatment, 2020.

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